Post-vaccination Immunity Against Hepatitis B Virus and Predictors for Non-responders Among Medical Staff
نویسندگان
چکیده
BACKGROUND Hepatitis B virus (HBV) is a major cause of chronic hepatitis, liver cirrhosis, and hepatocellular carcinoma (HCC). HB vaccination is an essential step in the prevention of the disease and its consequent complications. OBJECTIVES Immune status of medical personnel in teaching hospitals of Khuzestan is not well known. Since these personnel are usually at risk of needle stick and other high-risk events, some challenges exist in infection control committee with regard to managing these events. This study was conducted to assess post-vaccination immunity status and non-response to HBV vaccine as well as its predictors among medical staff in a teaching hospital affiliated to Ahvaz Jundishapur University of Medical Sciences (AJUMS) in Ahvaz, southwest Iran. PATIENTS AND METHODS In this retrospective cross-sectional study, the medical staff of a teaching hospital was evaluated for their immune response against HBV and factors affecting it. The study conducted in Razi Hospital, Ahvaz City, southwest of Iran, in 2013. Demographical, clinical, and laboratory data registered in medical files of hospital staff were analyzed by SPSS software version 16 using chi-square and Fisher exact tests. Differences with P value < 0.05 were considered significant. To identify predictors for non-responders, we used odds ratio (OR) with 95% confidence interval (CI). RESULTS Out of 239 participants, 43 (18 %) were men and 196 (82%) were women. Their mean age was 31.9 ± 18.1 years (range of 20 - 55 years). Fourteen (5.9%) participants were non-responders, 37 (15.5%) were poor responders, and 188 (78.6%) were good responders. The non-responders were older (> 50 years) than the responders (P = 0.0001), while the body mass index (BMI) was not significantly different (P = 0.37) between them. Diabetes mellitus (DM) (OR: 7.3, 95% CI, 1.3 - 41.7, P = 0.05), and using immunosuppressive drugs (ISD) (OR: 3.2, 95% CI, 1.1 - 11.5, P = 0.03) were two variables in association with non-response to HB vaccine. CONCLUSIONS Non-response rate to HB vaccine in our study was approximately 6%. Age over 50 years, DM, and receiving immunosuppressive drugs may be considered as predictors for non-response to HB vaccine in medical staff.
منابع مشابه
A Cross-Sectional Study on Anti Hepatitis B Immune Status in Vaccinated Healthcare Workers in the West Pomeranian Region of Poland
BACKGROUND Hepatitis B vaccination, recommended for medical staff, has a non-response rate of 5% to 32%. In Poland, there is no standardized postvaccination protocol to verify immunity. OBJECTIVES To determine the fraction of those who have been vaccinated against HBV (with a complete course followed/not followed by a booster) but not checked for serological evidence of hepatitis B immunity a...
متن کاملImmunogenicity of Hepatitis B Vaccine among Medical Staff of Shahid Madani Hospital of Tabriz, Iran
Background & Objectives: Vaccination is one of the best methods of prevention against hepatitis B virus. With respect to various vaccines against this virus and based on the differences of selected factors of immunogenicity, various studies on different groups in different locations is necessary. In present research, therefore the titer amount value of antibody against surface antigen of ...
متن کاملImmunity to Hepatitis B Vaccine in Thalassaemic Patients based on the Time Passed from Vaccination
Background & Aims: Hepatitis B virus is one of the causes of acute and chronic hepatitis. Due to multiple hospitalization and blood transfusion, thalassaemic patients are at higher risk of this infection. Duration of the immunity after vaccination in this high-risk group and the need for booster vaccination is uncertain. The aim of this study was to find antibody titration and immunity to Hepat...
متن کاملOccupational Stress Suppress Production of Anti-HBsAg Antibody in Nurse Staffs Following Hepatitis B Vaccination
Background and Objectives: Vaccination is the major strategy to protect nurses against infection with hepatitis B virus. However, some nurses do not produce sufficient amount of anti-HBsAg antibody required for immunity against infection. Chronic occupational stress has been proposed as a risk factor to humoral immunity. Given that nursing staff is exposed to occupational stress risk, this stud...
متن کاملAssessment of vaccination against hepatitis B and infection control compliance among dentists participated in 42nd international congress of Iranian dentists
Assessment of vaccination against hepatitis B and infection control compliance among dentists participated in 42nd international congress of Iranian dentists Dr. SM. Alavian* - Dr. H. Akbari ** - Dr. M. Ahmadzad asl*** - Dr. M. Kazem**** - A. Davoodi***** * - Associate Professor of Internal Medicine Dept. Faculty of Medicine, Baqyiatollah University of Medical Sciences. ** - Endodontist. *** - ...
متن کامل